PHINOMICS
Defining the Circulome to
Solve Disease
You
Your genome is the complete set of instructions encoded in DNA that makes you who you are. Most technologies cannot read all this information, leading to missing millions of lines of code in this human instruction manual.
Existing sequencing and informatics technologies, if not supplemented by other platforms, cannot capture a complete picture of the dynamic regions in our genome. These huge gaps in knowledge prevent advancements in personalized medicine.
Photo by Awab Husameldin on Unsplash
Solve your Circulome puzzle
Phinomics uses circular DNA, an early marker of genetic and environmental change, to diagnose disease and radically improve human health. By isolating and sequencing the circular genome ("the circulome", a term we coined), we solve a genetic puzzle that unlocks a universal “stage-zero” diagnostic for disease. At scale, circulome data will revolutionize diagnostics and identify new therapies.
Circular DNA
The human genome is classically depicted as a linear string. However, there exists a subset of the human genome that is circular and is currently missing from any picture we have of our genome. Despite the fact that these circular DNAs drive various pathologies, technological challenges have impeded focused efforts on these elements. Our work shows that the repertoire of circular elements or what is now called the circulome varies with disease and pathological state. Therefore the “circulome” is an invaluable diagnostic marker, a fingerprint for disease, and can be a novel target for new therapeutics.
Our Technology
Phinomics bridges engineering disciplines with immunology and cancer biology to prevent, diagnose, and treat disorders driven by changes in DNA.
We provide technologies that integrate single-cell DNA-analysis techniques with proprietary workflows, advanced bioinformatics, and leading instrumentation to uncover novel personalized details of genome structural and sequence rearrangements.
Early Cancer Detection
Defining the Circulome for Earliest Multicancer Detection
The biggest hurdle in cancer treatment is late detection. Phinomics is the only company that has novel experimental and informatics tools dedicated to capture the full cancer Circulome. We unlock a novel set of molecular markers that are cancer-type and stage-specific for the earliest detection of cancer. We also provide a map of previously uncharacterized genetic cancer drivers that can be targeted for therapeutics.