Circulomes

Recent work from our group shows that the repertoire of circular DNA (or as we coined, the Circulome) varies as a function of tissue type and health and disease- even within the same individual. This important discovery highlights the powerful impact the Circulome can play as a fingerprint of disease. It is clear that technologies that can unbiasedly isolate all circular DNA from any biological source, in addition to highly sensitive and rigorous informatic toolkits that can detect the slightest shifts in the Circulome, are needed to define the Circulome. Such platforms are technologically challenging but absolutely necessary to detect the slightest shifts in the Circulome and attribute causal elements to specific disease at the earliest sign. Phinomics, with our highly experienced team, is at the forefront of these transformative efforts.

While others point AI at the same biological data we’ve used for decades, Phinomics opens an entirely new layer of life—circular DNA and cryptic proteins—hidden in plain sight. We’re not just looking deeper; we’re redefining what’s visible, making the invisible biology of disease readable, learnable, and curable. By decoding these hidden drivers of disease, we’re making biology machine-readable and turning the invisible into the actionable.